(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid
Ziyuglycoside II
CAS: 35286-59-0
Molecular Formula: C35H56O8
(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid - Names and Identifiers
(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid - Physico-chemical Properties
| Molecular Formula | C35H56O8 |
| Molar Mass | 604.83 |
| Density | 1.25 |
| Melting Point | 260-263℃ |
| Boling Point | 716.2±60.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.2 in DMSO)+25 |
| Solubility | Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether. |
| Appearance | White crystal |
| pKa | 4.47±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD17214911 |
| Physical and Chemical Properties | White crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Sanguisorba. |
| In vitro study | Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC 50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells. Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent. Cell Viability Assay Cell Line: MDA-MB-435 cells Concentration: 10, 20, 30, 40, 50, 60 μM Incubation Time: 24 hours and 48 hours Result: The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Cell Cycle Analysis Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Induced G0/G1 and S phase arrest. Apoptosis Analysis Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: The apoptotic rate was significantly increased in comparison to that of the control. Western Blot Analysis Cell Line: MDA-MB-435 cells Concentration: 5, 10, 25 μM Incubation Time: 24 hours Result: Treatment resulted in increased expressions of both p53 and p21. |
(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid - Reference
| Reference Show more | 1. Tang Jun Zhang Jie Sun Wei Zhao Ang Zhu Zhiming Bao Xiao Wen Zhang Ming Ya Ma Bo. Simultaneous determination of Sanguisorba officinalis saponin Ⅰ and Sanguisorba officinalis saponin Ⅱ in rat plasma by LC-MS/MS and its pharmacokinetics [J]. Bioprocess 2019 17(05):536-541. 2. [IF = 2.26] Liao Wanqin et al."Ziyuglyside II exerts antiferative and antimetastasis effects on hepatocellular carcinoma cells." Anti-Cancer Drug. 2020 Sep;31(8):819-827 |
(3beta)-3-(alpha-L-Arabinopyranosyloxy)-19-hydroxyurs-12-en-28-oic acid - Reference Information
| biological activity | Ziyuglycoside II is a triterpene saponin compound extracted from Sanguisorba officinalis L. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis (apoptosis). It has anti-inflammatory and anti-cancer effects. |
| in vitro study | Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC 50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μ m and 4.74 μ m, respectively. Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h. Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells. Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is pose-dependent. cell Viability Assay Cell Line: MDA-MB-435 cells Concentration: 10, 20, 30, 40, 50, 60 μ m Incubation time: 24 hours and 48 hours result: the IC 50 at 24 h and 48 h was 5.92 μ m and 4.74 μ m, respectively. cell cycle Analysis cell line: MDA-MB-435 cells Concentration: 5, 10, 25 μ m Incubation time: 24 hours result: Induced g0/G1 and s phase arrest. Apoptosis Analysis cell line: MDA-MB-435 cells Concentration: 5, 10, 25 μ m Incubation time: 24 hours result: the apoptotic rate was significantly increased in comparison to that of the control. Western blot Analysis cell line: MDA-MB-435 cells Concentration: 5, 10, 25 μ m Incubation time: 24 hours result: Treatment resulted in increased expressions of both p53 and p21. |
| Cell Line: | MDA-MB-435 cells MDA-MB-435 cells MDA-MB-435 cells MDA-MB-435 cells |
| Concentration: | 10, 20, 30, 40, 50, 60 μM 5, 10, 25 μM 5, 10, 25 μM 5, 10, 25 μM |
| Incubation Time: | 24 hours and 48 hours 24 hours 24 hours 24 hours |
| Result: | The IC 50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Induced G0/G1 and S phase arrest. The apoptotic rate was significantly increased in comparison to that of the control. Treatment resulted in increased expressions of both p53 and p21. |
| chemical properties | white crystal, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Sanguisorba. |
| use | sanguisorba saponin Ⅱ has the effects of constricting blood vessels, hemostasis and antifungal. used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: It has a certain tyrosinase inhibition effect, protecting liver and choleretic effect. |
Last Update：2024-04-09 21:31:57
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CAS: 35286-59-0
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Mobile: 18021002903
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